|
KMID : 0043320110340010051
|
|
Archives of Pharmacal Research
2011 Volume.34 No. 1 p.51 ~ p.57
|
|
|
Solubility enhancement and physicochemical characterization of carvedilol solid dispersion with Gelucire 50/13
|
|
Potluri Raja Hemanth Kumar
Bandari Suresh
Jukanti Raju
Veerareddy Prabhakar Reddy
|
|
|
Abstract
|
|
|
|
The objective of the study was enhancement of dissolution of poorly soluble carvedilol by solid dispersions (SDs) with Gelucire 50/13 using solvent evaporation method. The solubility of carvedilol showed linear increase with increasing concentrations of Gelucire indicating AL type solubility diagrams. SDs characterized for physicochemical characteristics using differential scanning calorimetry and X-ray diffractometry revealed transformation of crystalline form of drug to amorphous form which was confirmed by scanning electron micrographs. Further fourier transform infrared spectroscopy results suggested there is no drug carrier interaction. From the dissolution parameters such as mean dissolution time, dissolution efficiency and drug release rate, improved dissolution characteristics for SDs were observed compared with physical mixture and pure drug. Thus SDs of carvedilol in Gelucire 50/13 showed enhanced solubility and dissolution rate compared to pure drug.
|
|
|
KEYWORD
|
|
|
Solid dispersion, Carvedilol, Gelucire, Dissolution
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|